Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
نویسندگان
چکیده
منابع مشابه
Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
Current knowledge indicates that the mammalian target of rapamycin (mTOR) functions as two complexes, mTORC1 and mTORC2, regulating cell growth, proliferation, survival, differentiation, and motility. Recently mSin1 has been identified as a critical component of mTORC2, which is essential for phosphorylation of Akt and other signaling molecules. Studies have shown that rapamycin inhibits phosph...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.3006